Giving truly informed consent to participate in a human-subject research project such as the PGP means understanding the risks associated with participating, not just the benefits. The PGP has every intention of following protocols that are carefully designed to minimize risk. However, participants should recognize that this project is exploring relatively unchartered territories and that there are risks, some that are not well understood. The PGP recommends that you discuss with your family members the risks associated with participating.

Personal genomics will have an impact on your privacy. The technology may allow for exposure of your unique genetic "fingerprint." This will have many implications. Consider the implications for the criminal justice system, for example. On the positive side, criminals can be more easily prosecuted and convicted when DNA evidence is available. On the negative side, someone could, in theory, make synthetic DNA corresponding to your DNA and plant it at a crime scene, thus falsely incriminating you. Your DNA could also infer unexpected paternity or your relationship to a criminal or historic figure of dubious fame.