Another benefit of participating in the PGP is personal knowledge. Although the PGP does not expect the results to necessarily have any useful medical purpose for any particular individual, participants will nonetheless learn about their own genetic makeup. Participants may learn about their risk for getting genetic disorders and make lifestyle changes to reduce the risk.

PGP researchers may have access to Web-based interpretation tools that can identify genetic variations and associate them with traits or diseases. These data may be made available to PGP participants who can discuss the results with their personal doctors or genetic counselors. Results may also be discussed in online forums or blogs with researchers or other participants. People with shared genetic variations or mutations may wish to contact each other and discuss diseases, traits, or genealogy.