Personal Genome Project Study Guide
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Part I: Genetic Material

Part II: Gene Transmission

Part III: Gene Expression

Part IV: Genetic Regulation

Part V: Genetics and Society

Part VI: Project Literacy





Part IV: Gene Regulation
Lesson 8: Controlling Protein-Coding Genes
                 Practice Test
Question 1:
1.An increase in gene expression means
  A.There will be more DNA in the gene.
  B.The trait associated with the gene
            will be increasingly obvious.
  C.There will be more of the protein
a.            that is encoded by the gene.
  D.The likelihood of inheriting the
a.            trait will be increased.
Question 2:
2.The human body has many different types of cells
  A.And many types of genomes.
  B.And each cell type has different             genes turned off or on.
  C.And each cell type is the result of             environmental gene regulation.
   D.All of the above are correct.
Question 3:
In what way(s) can gene expression be altered?
  A.A mutation prevents the                         transcription of a gene.
  B.Factors in the environment influence             gene expression.
  C.A chromosomal duplication increases             gene copy number.
  D.All of these are ways that gene             expression can be altered.
Question 4:
After complete exome sequencing and analysis, an individual was found to have seven recessive mutations known to cause seven different diseases.  The individual was heterozygous for all seven genes; the other alleles were normal.  This means that
  A.The individual has the seven genetic             diseases.
  B.Because the mutations are
recessive, none of the diseases is             likely to develop.
  C.There is a high likelihood that at             least some of the diseases will             develop.
  D.The diseases can be avoided only if             a healthy lifestyle is adopted.
Question 5:
Several different mutations in the LDL receptor gene are dominant-acting and known to be associated with development of high blood cholesterol and heart disease.  If a person has one of these disease-associated mutations
  A.They will not be at risk for the              disease if they have a healthy diet.
  B.They are at increased risk for the             disease but can reduce their risk if             they have a healthy diet.
  C.Regardless of their diet, they will             get the disease.
  D.They are not at risk for the disease             unless they do not also have a             normal allele.