Personal Genome Project Study Guide
Part IV: Gene
Lesson 8: Controlling Protein-Coding Genes
An increase in gene expression means
will be more DNA in the gene.
The trait associated with the gene
will be increasingly obvious.
There will be more of the protein
that is encoded by the gene.
The likelihood of inheriting the
trait will be increased.
The human body has many different types of cells
And many types of genomes.
And each cell type has different
genes turned off or on.
And each cell type is the result of
environmental gene regulation.
All of the above are correct.
In what way(s) can gene expression be altered?
A mutation prevents the
transcription of a gene.
Factors in the environment influence
A chromosomal duplication increases
gene copy number.
All of these
are ways that gene
expression can be altered.
After complete exome sequencing and analysis, an individual was found to have seven recessive mutations
known to cause seven different diseases.
The individual was heterozygous for all seven genes; the other alleles were normal.
This means that
The individual has the seven genetic
Because the mutations are
recessive, none of the diseases is
likely to develop.
There is a high likelihood that at
least some of the diseases will
The diseases can be avoided only if
a healthy lifestyle is adopted.
Several different mutations in the LDL receptor gene are dominant-acting and known to be associated with
development of high blood cholesterol and heart disease.
If a person has one of these disease-associated mutations
They will not be at risk for the
disease if they have a healthy diet.
They are at increased risk for the
disease but can reduce their risk if
they have a healthy diet.
Regardless of their diet, they will
get the disease.
They are not at risk for the disease
unless they do not also have a